Dr Greg Longmore’s team in the USA supported these findings, using a mouse without the LMID1 gene which developed lung cancer.
 
Dr Sharp said: “The LIMD1 gene studied in this research is located on part of chromosome 3, called 3p21.
 
“Chromosome 3p21 is often deleted very early on in the development of lung cancer due to the toxic chemicals in cigarettes, which implies that inactivation of LIMD1 could be a particularly important event in early stages of lung cancer development.
 
“We are now going to extend these finding by developing LIMD1 as a novel prognostic tool for detection of early stage lung cancer.”
 
Lung cancer is the UK’s biggest cancer killer, claiming around 33,600 lives a year. Ninety per cent of cases are caused by smoking. At present lung cancer is often detected late, meaning that 80 per cent of patients die within a year of being diagnosed.
 
Dame Helena Shovelton, Chief Executive of the British Lung Foundation said: “This is very exciting research which could lead to the development of early screening techniques and treatments for lung cancer. We are very proud to have made this breakthrough possible”.


— Ends —

Notes to editors: The University of Nottingham is ranked in the UK's Top 10 and the World's Top 100 universities by the Shanghai Jiao Tong (SJTU) and Times Higher (THE) World University Rankings.

It provides innovative and top quality teaching, undertakes world-changing research, and attracts talented staff and students from 150 nations. Described by The Times as Britain's "only truly global university", it has invested continuously in award-winning campuses in the United Kingdom, China and Malaysia. Twice since 2003 its research and teaching academics have won Nobel Prizes. The University has won the Queen's Award for Enterprise in both 2006 (International Trade) and 2007 (Innovation — School of Pharmacy), and was named Entrepreneurial University of the Year at the Times Higher Education Awards 2008.
 
Its students are much in demand from 'blue-chip' employers. Winners of Students in Free Enterprise for four years in succession, and current holder of UK Graduate of the Year, they are accomplished artists, scientists, engineers, entrepreneurs, innovators and fundraisers. Nottingham graduates consistently excel in business, the media, the arts and sport. Undergraduate and postgraduate degree completion rates are amongst the highest in the United Kingdom.

The British Lung Foundation is the only UK charity working for everyone affected by lung disease. The charity focuses its resources on providing support for people affected by lung disease today; and works in a variety of ways (including funding world-class research) to bring about positive change, to improve treatment, care and support for people affected by lung disease in the future. It provides information via the website www.lunguk.org and telephone helpline 08458 50 50 20.